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Not only its amount but will also the useful Homes of Hb impact general performance. This is certainly illustrated by the observation that a heightened Hb-O2 affinity favors O2 loading from the lung and survival in an hypoxic setting (Eaton et al., 1974; Hebbel et al., 1978), While a lessened Hb-O2 affinity favors the discharge of O2 within the Hb